Imipramine – Comprehensive Overview

When working with Imipramine, a tricyclic antidepressant prescribed for major depressive disorder, nocturnal enuresis, and certain chronic‑pain conditions. Also known as Tofranil, it belongs to the Tricyclic antidepressant class and directly targets Depression, a mood disorder marked by persistent low mood and loss of interest. Like many psychotropic agents, Side effects—dry mouth, dizziness, constipation, or cardiac rhythm changes—can shape how patients use the drug. Knowing these core elements helps you decide when Imipramine fits your treatment plan and what to watch for during therapy.

Key aspects you should consider

First, dosage matters. Physicians usually start with a low dose, such as 25 mg daily, and increase gradually to 150 mg or more, depending on response and tolerability. The goal is to hit the therapeutic window without triggering excessive anticholinergic effects. Timing also plays a role; many clinicians recommend taking the dose at bedtime because the sedating effect can improve sleep quality, especially for patients battling insomnia alongside depression.

Second, drug interactions are a real concern. Imipramine is metabolized by CYP2D6, so co‑administration with strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) can raise blood levels and heighten side‑effect risk. Conversely, CYP2D6 inducers like carbamazepine may lower effectiveness. Always review a patient’s full medication list—over‑the‑counter antihistamines, decongestants, or certain herbal supplements can amplify anticholinergic burden.

Third, monitoring is essential. Baseline ECG is recommended for anyone with heart disease, because tricyclics can prolong the QT interval. Regular blood pressure and heart‑rate checks help catch early signs of arrhythmia. For older adults, start even lower—often 10–25 mg—and assess cognition frequently, as Imipramine can cause confusion or worsen glaucoma.

Finally, compare Imipramine with newer agents. Selective serotonin reuptake inhibitors (SSRIs) like sertraline or SNRI duloxetine tend to have milder side‑effect profiles, but they may be less effective for certain chronic‑pain syndromes where Imipramine shines. If a patient has tried multiple SSRIs without relief, revisiting a tricyclic can be a logical next step.

All these factors—dose titration, interaction awareness, safety monitoring, and comparative positioning—form the practical framework you’ll see reflected across the articles below. Whether you’re looking for a side‑by‑side drug comparison, tips for managing gout while on prescription meds, or guidance on buying affordable generics, the collection offers actionable insights that build on the fundamentals of Imipramine therapy.

Scroll down to explore detailed guides, comparison tables, and real‑world advice that will help you make informed decisions about Imipramine and related treatments.