Eflornithine (Vaniqa): What it does and when to use it

Want to slow unwanted facial hair without a clinic procedure? Eflornithine cream (brand name Vaniqa) can help. It doesn’t remove hair instantly, but it slows new growth so plucking and shaving feel easier over time. It’s a prescription topical usually used by women with facial hirsutism.

How eflornithine works

Eflornithine blocks an enzyme involved in hair growth. Applied to the skin twice a day, it reduces the rate that hairs grow and makes them finer. Expect to see changes after about 4–8 weeks, and clearer results around 12–16 weeks. If you stop using it, hair growth typically returns to previous levels in a few weeks to months.

For non-dermatology uses, a different form of eflornithine (given by IV) has been used to treat African sleeping sickness. That’s a separate, hospital-level treatment and not the same as the cream you get for facial hair.

Using eflornithine safely

Follow your prescriber’s directions. Common tips: wash and dry the area before applying, use a thin layer, and avoid eyes, mouth, and mucous membranes. Don’t apply to broken or irritated skin. If you use other topical treatments (like retinoids), tell your doctor—some combinations can increase irritation.

Side effects are usually local: skin redness, stinging, burning, or acne-like eruptions. Most people tolerate it well, but if you get severe irritation, swelling, or signs of infection, stop and call your prescriber. If you’re pregnant, planning pregnancy, or breastfeeding, discuss risks with your doctor—most clinicians avoid starting it during pregnancy.

Eflornithine cream is prescription-only in many countries. That helps ensure the cause of extra hair is checked—conditions like polycystic ovary syndrome (PCOS) or hormonal issues can cause excess facial hair and need medical evaluation. A doctor can also confirm this cream is a good fit for you.

Pairing eflornithine with hair removal methods can speed up visible results. Many people keep shaving or using tweezers while the cream gradually reduces growth. Some also combine it with long-term options like laser hair removal; ask your dermatologist for a plan tailored to your skin type and goals.

Final practical notes: give it time, be consistent with twice-daily use, and protect treated skin from irritation. If cost or access is an issue, ask your clinician about samples, alternatives, or whether an insurance plan covers it. For anything unexpected—worsening symptoms, allergic reaction, or new skin problems—stop use and seek medical advice.