Cefixime: what it treats and how to use it safely

Cefixime is an oral third‑generation cephalosporin antibiotic used for common infections like ear infections (otitis media), throat infections, sinusitis, uncomplicated urinary tract infections, and some cases of gonorrhea. It fights bacteria by stopping their cell wall formation. It won't work for viral infections such as colds or flu.

How to take cefixime

Follow your prescriber’s instructions — that’s the safest rule. Typical adult dosing is 400 mg once daily or 200 mg twice daily, depending on the infection. For uncomplicated gonorrhea many guidelines recommend a single 400 mg dose, but local resistance patterns and local guidance matter. For children dosing is weight‑based; a common regimen is about 8 mg/kg per day, split into one or two doses. Don’t double up if you miss one dose — take the next dose at the scheduled time.

Take tablets with or without food. If you have the oral suspension, shake well and use a proper measuring spoon. Reconstituted suspension usually needs refrigeration and should be used within 7 days — check the label for exact storage instructions.

Side effects, warnings, and interactions

Most people tolerate cefixime well. The common side effects are nausea, diarrhea, stomach pain, and occasional rash. If you get severe diarrhea — especially watery or bloody stool — stop the drug and contact your doctor right away; this could signal Clostridioides difficile infection.

Allergic reactions can happen. If you develop hives, swelling of the face or throat, trouble breathing, or a severe skin reaction, seek emergency care.

Cefixime can interact with blood thinners like warfarin and may increase bleeding risk; your doctor may monitor INR. Dose adjustment is recommended if you have significant kidney disease. Tell your prescriber about any liver or kidney problems before starting treatment.

Cross‑reactivity with penicillins is low but possible. If you have a history of a severe penicillin allergy, discuss alternatives with your clinician rather than assuming cefixime is safe.

Pregnancy and breastfeeding: doctors often consider cefixime safe in pregnancy when clearly needed. Small amounts may pass into breast milk; most guidelines say it’s acceptable, but mention it to your provider so they can weigh risks and benefits.

Resistance is a growing issue. Some bacteria, especially strains causing gonorrhea or certain urinary infections, may be resistant to cefixime. Culture and sensitivity testing helps pick the right antibiotic when infections are severe or not improving.

Finish the full course even if you feel better, unless your doctor tells you otherwise. Stopping early raises the chance the infection returns and encourages resistance.

Buying antibiotics online? Use a reputable pharmacy and a valid prescription. Avoid sellers that offer antibiotics without a prescription or unusually cheap, unbranded pills — your health matters more than a bargain.

If symptoms worsen, fever persists beyond 48–72 hours, or you notice severe side effects, contact your healthcare provider. Clear communication and following instructions keep treatment effective and safe.

The cost of cefixime: understanding pricing and insurance coverage

As a blogger, I recently explored the cost of cefixime, a commonly prescribed antibiotic. I discovered that pricing can vary significantly depending on factors such as location, pharmacies, and manufacturer. Additionally, I found that insurance coverage plays a crucial role in the affordability of this medication. For those without insurance or with high deductibles, the cost of cefixime can be a burden. It's essential for patients to research and compare prices to find the best deal, and consider generic options for more affordable alternatives.

Keep Reading